TBI Timeline Of Cascading Events

Traumatic Brain Injury is a neurological disorder characterized by brain damage that results in a disruption in neural functioning. It is often caused by blunt force trauma, typically due to a car accident or sports injury. TBI exceeds that of all other health diseases with an annual incidence of 1.7 million new cases and of those, 50,000 cases result in death. It is an extremely serious disorder that may result in a wide array of symptoms that may include: loss of consciousness, persistent headaches, seizures, nausea and vomiting, diminished cognitive functioning, behavioral changes, and neurodegenerative disease.

Following a TBI, a cascade of events occurs. This timeline is as follows:

Tissue Damage

Possible Damage to the Nerves
Possible Damage to the Blood Supply
Possible Tissue Death

Increased Inflammation
Increased Swelling
Increased Damage to the Mitochondria
Increased Free Radicals

Tissue Damage
Damage to the Cells
Possible Tissue Death

Research suggests that following a ketogenic diet may provide numerous benefits during this cascade of events. Ketones may aid in protecting the brain by reducing inflammation and providing an alternative fuel source to neurons while glucose uptake and use are impaired.


Giza, C. C., & Hovda, D. A. (2014). The new neurometabolic cascade of concussion. Neurosurgery, 75 Suppl 4(0 4), S24–S33.