The Ketogenic Diet (KD) has been used as a treatment option for refractory epilepsy since the 1920s. In the past few years, there has been an increase in research looking at other applications of this dietary approach. There is mounting evidence to show the therapeutic potential of the ketogenic diet in the management of Alzheimer’s Disease (AD), Parkinson’s Disease (PD), amyotrophic lateral sclerosis (ALS) and certain types of cancers (1,2). Most recently, the use of the Ketogenic Diet as a therapeutic treatment option for progressive Multiple Sclerosis has been brought into light (3).
What is Multiple Sclerosis
Multiple Sclerosis is a chronic inflammatory disease of the Central Nervous System (CNS) resulting in neurodegeneration that affects over 2 million people worldwide. MS disrupts the flow of information being transmitted in the brain and between the brain and the rest of the body. The exact reasons for the development of MS are still not fully understood, although it is thought to be triggered by one or more environmental factors in genetically susceptible people and seems to affect more women than men.
Symptoms of Multiple Sclerosis
People with the disease tend to exhibit one of four disease courses with symptoms ranging from mild to severe. Because MS has traditionally been viewed as an immune-mediated inflammatory disease, the majority of the Disease Modifying Treatments (DMTs) is predominantly based on immunosuppressive medications. While this has been proven to be effective in people with relapsing forms of MS, the treatments are not always effective for progressive forms.
Multiple Sclerosis Potential Causes
As seen in AD and Parkinson’s disease, the presence of glucose hypo-metabolism (decreased metabolism) is a possible causative factor in the neuro-degeneration process that underlies progressive MS (3). Glucose hypo-metabolism occurs when the brain is no longer able to use glucose as its main energy source. This phenomenon has been evident in the brain of AD patients for many years but was always thought of as a consequence of the disorder – not a cause. New and emerging research (4) shows this may not be the case. The same may be true for patients with MS.
Although it is often stated that the brain can only use glucose as its energy source, this is factually incorrect. In fact, the brain can use two different types of fuel; one being glucose and the other being ketone bodies. If a major reason for the progression of MS is glucose hypo-metabolism, then boosting the energy supply through an alternative such as ketone bodies could suggest a potential therapeutic advantage.
Multiple Sclerosis and Ketone Bodies
The body can produce ketone bodies through periods of starvation or by following a carbohydrate-restricted diet. Fat is unable to be used as a direct energy source for the CNS and instead will eventually be converted into ketone bodies through a process known as ketogenesis. Ketosis generally occurs in the mitochondria of the liver and results in the production of the ketone bodies such as beta-hydroxybutyrate and acetoacetate. This state of ketosis should not be mistaken for diabetic ketoacidosis, which is characterized by ketonemia of 20mmol/L or greater (compared to 8mmol/L in ketosis) and results in acidosis. Following ketogenesis, ketone bodies can then cross the blood brain barrier (BBB), which protects the brain from things like toxins and are utilized very efficiently by the brain.
At present, there are few studies that have looked at the direct effects of ketone bodies or the ketogenic diet in Multiple Sclerosis. One study demonstrated improvements in memory dysfunction and motor impairment in a specific MS animal model (5), as well as decreasing inflammation within the brain. More recently, a different study examined humans with relapsing, remitting MS implement a KD in conjunction with fasting (6). These researchers found that these dietary approaches improved quality of life and decreased fatigue, one of the most reported debilitating symptoms of MS.
These are just two studies (only one of which was conducted in humans) with differing limitations and so we cannot conclude emphatically that the KD is a viable therapeutic treatment over and above alternative options. However, that being said, it is quite clear that there does exist great potential for new research to delve further into this topic. The KD and ketone bodies themselves have been shown to be safe and effective in other neurological disorders. Given the lack of available treatment for the progressive symptoms associated with MS and the relatively safe option of a KD, exploring the use of this diet does deserve further investigation within Multiple Sclerosis.
- MS is a disease of the CNS that results in chronic inflammation and neurodegeneration.
- There are four different disease courses that MS patients can endure, but brain hypometabolism seems to be the most common characteristic.
- Ketosis can result in an alternative fuel source for the CNS that can fill the brain’s energy deficit that occurs from hypometabolism.
- Animal studies have demonstrated that the ketogenic diet can improve memory dysfunction, motor impairment, inflammation, and quality of life.
- More research is needed in the area of ketogenic dieting and neurodegenerative diseases, especially MS.
- Paoli, A., Rubini, A., Volek, J. S., & Grimaldi, K. A. (2013). Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. European journal of clinical nutrition, 67(8), 789-796.
- Seyfried, T. N. (2014). Ketone strong: emerging evidence for a therapeutic role of ketone bodies in neurological and neurodegenerative diseases. Journal of lipid research, 55(9), 1815-1817.
- Storoni, M., & Plant, G. T. (2015). The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis. Multiple sclerosis international, 2015.
- Cunnane, S., Nugent, S., Roy, M., Courchesne-Loyer, A., Croteau, E., Tremblay, S., ... & Begdouri, H. (2011). Brain fuel metabolism, aging, and Alzheimer’s disease. Nutrition, 27(1), 3-20.
- Hao, J., Liu, R., Turner, G., Shi, F. D., & Rho, J. M. (2012). Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLoS One, 7(5), e35476.
- Choi, I. Y., Piccio, L., Childress, P., Bollman, B., Ghosh, A., Brandhorst, S., ... & Wei, M. (2016). A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell reports, 15(10), 2136-2146.