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Supplementing with Caffeine on Keto

  Published on May 19th, 2020
  Reading time: 2 minutes
  Last modified April 15th, 2021

What is Caffeine?

Caffeine is an alkaloid that is found in the leaves, seeds, and nuts of many plants. Caffeine functions as an adenosine receptor antagonist. This means that caffeine binds to adenosine receptors and prevents adenosine from being able to bind itself. When adenosine binds to its receptor, it causes the downregulation of central nervous system (CNS) activity and thus stimulates parasympathetic functioning. This is what causes your body to feel tired or sleepy. When caffeine binds to this receptor, adenosine can no longer bind and thus CNS activity is not lessened, which causes you to feel more awake.

What are the Benefits of Caffeine?

Whether you are on the keto diet or not, consuming caffeine has numerous benefits, including the following: (1,2,3)

  • Increase wakefulness and alertness
  • Increase thermogenesis
  • Increase fat oxidation
  • Reduce inflammation
  • Increase free fatty acids during rest
  • Improve exercise performance

Is Caffeine Keto-Friendly?

Yes, caffeine is keto-friendly. In fact, some research actually suggests that caffeine could increase ketone production. (4)

How Can I Supplement with Caffeine?

The easiest way to supplement with caffeine on keto is to take caffeine tablets. Most caffeine tablets provide 100-250mg of caffeine.

The tastiest way to supplement with caffeine is to enjoy a cup of coffee! The average cup of coffee contains ~75-100mg of caffeine per 8fl oz.


caffeine science


Want to Know More About Supplementing with Caffeine on Keto?

Check out our full article: Keto Supplements: Which Are Beneficial and Which Are a Scam?



1) Liu Y, Burger SK, Ayers PW, Vohringer-Martinez E. Computational study of the binding modes of caffeine to the adenosine A2A receptor. J Phys Chem B. 2011;115(47):13880–90. pmid:21970461

2) Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr. 1990;51(5):759‐767. doi:10.1093/ajcn/51.5.759

3)Norager CB, Jensen MB, Weimann A, Madsen MR. Metabolic effects of caffeine ingestion and physical work in 75-year old citizens. A randomized, double-blind, placebo-controlled, cross-over study. Clin Endocrinol (Oxf). 2006;65(2):223‐228. doi:10.1111/j.1365-2265.2006.02579.x

4) Vandenberghe C, St-Pierre V, Courchesne-Loyer A, Hennebelle M, Castellano CA, Cunnane SC. 2017a. Caffeine intake increases plasma ketones: an acute metabolic study in humans. Can. J. Physiol. Pharmacol. 95: 455-458 


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