A ketogenic diet (also known as the keto diet) is typically lower in carbohydrates and higher in fats than a standard American diet. Once your body adapts to a ketogenic diet, it switches from primarily using carbohydrates and glucose to fat and ketones as fuel. This adaptation within the body increases fat breakdown and oxidation, which can improve body composition, general health, performance, and perhaps even longevity! The amount of fat, carbohydrates, and protein needed to achieve a well-formulated keto diet for beginners differs from person to person and is goal-dependent. Any dietary protocol in which you are lowering carbohydrates sufficiently enough to induce a state of ketosis can be considered a ketogenic diet. However, throughout this guide you will begin to understand how to construct a well-formulated ketogenic diet to meet your goals.
There exists great debate on how to quantify the macronutrient ratios and percentages for a traditional ketogenic diet. Despite numerous opinions, the common and ultimate objective is to develop a diet that is sustainable in achieving the desired outcome (i.e., a state of ketosis). As such, while it is suggested that 65–80% of the total calories come from fat, and 15–30% from protein, these numbers will be optimized according to every individual’s unique metabolic needs. For example, an individual who is trying to achieve a state of ketosis might have a different ratio of macronutrient requirements than someone who is using a ketogenic diet to improve their body composition. Once the body begins to use fat as its primary fuel source, metabolic “keto-adaptation” characterized by increased production of ketones takes place. It is important to note that there is no “optimal” level of ketosis, nor is there a standard macronutrient profile to achieve a ketogenic state, because factors such as activity level, body composition, and desired health and performance outcomes will influence these variables. Although individualized, ketogenic.com currently offers a Keto Calculator that can help provide you with a starting point on your macronutrients.
As a quick example, if you are consuming 2,000 calories per day utilizing 70% Fat, 25% protein, and 5% carbohydrates, your intake would look like the following:
Keep in mind that this is just an example and certainly will be different for every person depending on his or her goals and biology.
When dietary carbohydrate is broken down into the energy substrate glucose, thereby raising blood glucose levels, the pancreas is stimulated to secrete insulin (the hormone that stores fat and inhibits ketone production). However, when carbohydrate intake is restricted, insulin remains suppressed, and the body’s primary fuel source shifts from glucose to fat, priming the body to enter a state of ketosis. When fat oxidation/breakdown is increased to a certain extent, ketones are made in the liver through a process known as ketogenesis (i.e., keto + genesis = ketone formation). When carbohydrate intake is restricted, blood glucose and insulin levels decrease, which allows fat stores to be broken down rapidly for energy. Most cells in the body can utilize either fatty acids or ketones for fuel, including the brain, which has shown to be more efficient in the presence of ketones rather than glucose.
In order to maximize the benefits of a keto diet for beginners, self-experimentation to achieve an optimal level of ketosis is important. In addition to quantifying blood ketone levels, there are several biological changes that your body will experience to help identify a ketogenic state. These changes will be more robust for some. In contrast to the negative side effects often experienced while on other low-carbohydrate diets, a ketogenic state and “keto-adaptation” can elicit euphoric effects including:
To determine whether or not you are in ketosis, there are several methods of measuring ketone levels, as noted below:
Optimal Ketone Range: As with other facets of the keto diet for beginners, the optimal ketone levels will vary on an individual basis. However, literature typically suggests that mild nutritional ketosis will begin once blood ketones are around 0.3–0.5 mmol/L. Upon “keto-adaptation,” this value may increase to around 1.0–3.0 mmol/L; however, that’s not always necessarily the case. If an individual is following a ketogenic diet strictly for therapeutic reasons, one may consider trying to achieve a deeper level of ketosis, but even those with a strict regimen may see only slight elevations in ketones due to rapid uptake into tissues.
Testing ketones may be a good way to initially determine one’s metabolic state of ketosis; however, as mentioned above, since the “optimal” level of ketones varies among individuals, daily ketone testing is not necessary.
There are several different methods in which the body can enter the metabolic state of ketosis.
Fasting ketosis: Fasting ketosis, also referred to as starvation ketosis, played a major role in the development of the keto diet for beginners. The concept of fasting has been around for centuries and can be traced back to biblical times. By definition, fasting is the absence of caloric consumption for a period of time. This can range from several hours to several days and can have profound effects on the degree of ketosis. As the duration of the fasting increases, so does the production of ketones, and thus a deeper ketogenic state is obtained. As such, the mechanisms of ketone production are similar between fasting and dietary applications similar to keto diet for beginners, both of which result in lower and more stable levels of insulin and blood glucose accompanied by fat metabolism.
A monumental study by George Cahill found that as fasting time increases, the level of ketone production also increases (eventually stabilizing). Spanning a period of 40 days, this landmark study is a prime example of the safety of the ketogenic diet for a majority of individuals.
Nutritional ketosis: Nutritional ketosis is classified as any dietary application that elicits the metabolic state of ketosis via ingestion of food, supplements, or beverages. There are three sub-types of nutritional ketosis:
Carbohydrate-restricted ketosis: This type of ketosis mimics the same biological alterations seen during lengthy fasts, but without the complete restriction of food. Carbohydrate-restricted ketosis is achieved primarily through a very low-carbohydrate ketogenic diet. This restriction, in turn, results in reductions of insulin and blood glucose levels similar to that of fasting, which again increases blood ketone levels. For most individuals, nutritional ketosis is much more sustainable than fasting or starvation ketosis. Fasting can still have its place in a keto diet for beginners. Many individuals following a ketogenic diet like to implement a regular fasting protocol such as intermittent fasting (IF) (12–20 hours daily) or every-other-day fasts (EOD), depending on their goals. This practice is not critical for success on a ketogenic diet, but it can enhance the level of ketone production, and thus magnify the benefits.
Supplemental ketosis: This form of ketosis has recently gained momentum in the field of ketogenic dieting. Supplemental ketosis is a ketogenic state that is achieved through the ingestion of ketogenic supplements. Consuming these substances alone does not mean that an individual is “keto-adapted.” While these products can help during the keto-adaptation period, especially if one is experiencing the “keto-flu,” they will only elicit short-term increases in blood ketone levels. Exogenous ketones can acutely produce benefits similar to the ketogenic diet; however, these products are best used in conjunction with a well-formulated keto diet for beginners, or the very at least, a diet that restricts carbohydrates. The commonly used supplements on the market are medium-chain triglyceride (MCT) oil and exogenous ketones. MCT oil is a fat that, in contrast to other longer-chain fatty acids, travels straight from the intestines to the liver where it is readily metabolized. This allows for ketone production in the liver to occur faster than with other fats (long-chain fatty acids have to travel through the lymph and circulatory systems first). Exogenous ketones are synthetic substances that mimic the ketones produced in our body (endogenous ketones). Exogenous ketones can come in the form of ketone salts or ketone esters.
Alcoholic ketoacidosis (AKA): AKA is a ketone-producing state that may occur following excessive alcohol consumption for long periods of time. When alcohol is metabolized in the liver, ketones are produced. Furthermore, as with other ketogenic states, certain biological changes, specifically at the hormonal level, occur to promote fat metabolism and ketone production. It is critical to note that AKA will not occur if the alcohol consumption is coupled with sugar.
Note: ketogenic.com does NOT recommend or promote the consumption of alcohol to produce or augment a ketogenic state.
Diabetic Ketoacidosis: Diabetic ketoacidosis (DKA) is the variation of ketosis that is responsible for deterring many people from considering the adoption of a keto diet. DKA occurs primarily in those suffering from Type 1 diabetes. The inability to secrete insulin prevents ingested carbohydrates (glucose) from entering our insulin-dependent cells (i.e., muscle and adipose tissue) as a substrate for energy production. Due to this induced cellular starvation, the body will begin to produce ketones at an uncontrolled rate.
Detrimentally, this results in high levels of both ketones and glucose. Extremely high ketone levels in the blood will elicit a dangerous biological environment that can even result in death. It must be clarified that DKA is very different than nutritional ketosis or fasting ketosis; ketone levels cannot be produced at such high levels in healthy individuals as they are with those in DKA.
The confusion between ketosis and ketoacidosis is a prominent reason why many individuals, particularly doctors, steer clear of the keto diet for beginners. It’s important to understand that these are two very DIFFERENT metabolic states. Ketoacidosis may occur in uncontrolled type 1 diabetics (DKA; diabetic ketoacidosis) due to insulin deficiencies. DKA is associated with both elevated blood glucose and ketone levels; due to little to no insulin production, blood glucose cannot enter insulin-dependent cells to be used for energy, and as such, cells become hungry, resulting in uncontrolled ketone production. In turn, a highly acidic environment is created that can have detrimental effects on an individual’s health, possibly resulting in death. It must be echoed that the ketogenic diet, which induces “nutritional” ketosis, is vastly different and should never be confused with DKA. To put this in perspective, a normal state of ketosis, as achieved via the keto diet for beginners may elevate ketones anywhere from 0.3–5mM, while DKA results in ketone levels of about 15mM or higher.
While a keto diet for beginners is also low in carbohydrates, it is NOT synonymous with traditional low-carbohydrate diets seen in popular media or even some scientific research. Since there is no strict definition of a “low carbohydrate diet,” some research studies utilize 30–40% carbohydrate diets and indicate that they are “low-carb.” However we now know that is roughly the same percentage as a standard American diet that has plagued our society with obesity and metabolic syndrome. Thus, while lowering carbohydrate intake in general is beneficial, it must be reinforced that traditional low-carbohydrate diets DIFFER from a well-formulated ketogenic diet.
In most cases, the macronutrient profile for a keto diet for beginners consists of about 5–10% carbohydrates, 15–25% protein, and the remaining 65–80% from fat. By restricting glucogenic substrates (i.e. nutrients that increase blood glucose levels, like carbohydrates and glucogenic amino acids from proteins), a deeper level of ketosis can be achieved, which may have a plethora of benefits as discussed below. As an example, one study compared diets with 30, 60, and 100 grams of carbohydrates per day and found that restricting carbohydrates to 30 grams led to a greater increase in circulating ketone levels and body fat loss.
The Atkins diet and ketogenic diet are often used synonymously; however, they are different. While both diets lower carbohydrate consumption, the Atkins diet allows for a period in which both protein and carbohydrate intakes are increased (while fat intake is lowered) beyond what would classify as ketogenic. The goal of the ketogenic diet is to shift the body into utilizing fat/ketones as its primary fuel source. By doing so, the body creates a metabolic substrate called ketone bodies. However, due to the increase of both carbohydrates and protein as well as lowered intake of fat, the Atkins diet is metabolically different from a keto diet and often does not result in a consistent state of ketosis.
In addition to the traditional ketogenic and Atkins diets described above, there are modifications that can be implemented to both of these diets in order to produce greater benefits on an individual basis. One such amendment, called the Modified Atkins Diet (MAD), is structured similarly to the Atkins diet where protein and fat are consumed freely but carbohydrate intake is further restricted, providing an intermediary diet between Atkins and ketogenic diet. This approach is commonly being used with great success among children with epilepsy due to its ability to increase the likelihood of adherence to the diet while still minimizing glucose intake from dietary carbohydrates.
There are several strategies for transitioning into a ketogenic state. Depending on a variety of factors and lifestyle habits, some beginners choose to ease into the process by adopting a low carbohydrate diet prior to implementing a full keto diet. One place to start would be to eliminate sugary, processed foods and replace those with whole, lower-carbohydrate foods. In doing so, you will begin to understand the keto diet for beginners, and once ready, you can dive into and customize the diet. To aid in the transition of a ketogenic lifestyle, our Keto Calculator is an excellent resource!
Lowering carbohydrate intake can provide several health benefits. When in a state of ketosis, your body is rapidly producing and/or utilizing ketones as a fuel source. Due to this superior source of fuel (ketones), people tend to experience a variety of benefits more robustly than if they were just eating a low-carbohydrate, non-ketogenic diet:
Increased Energy: Fat and ketone bodies can be utilized as a fuel source for nearly all of the cells in the body. Once the body begins to use ketones as its primary fuel source, there will be a noticeable increase in energy since you are avoiding the ups and downs associated with high-carbohydrate/high-glucose/high-insulin levels that result in feeling lethargic and tired throughout the day.
Cognitive Enhancement: Ketones may be the preferred fuel source for the brain. Due to the brain’s preference to uptake and utilize ketones as fuel it is very common for individuals to report an increase in cognitive performance. This is even more common in individuals with some degree of insulin resistance, as their brain is likely unable to effectively utilize glucose as a sole fuel source due to the resistance.
Appetite Control: The high-fat nature of the ketogenic diet along with elevated ketone and stable blood glucose levels have been shown to have a profound effect on appetite. This may give individuals who have a difficult time controlling the amount of food they eat “freedom” in knowing that they won’t be as hungry and thus less likely to consume excess calories.
Body Composition: Physical changes in the body are one of the primary reasons people are attracted to and implement low-carbohydrate diets. By definition, being in a state of ketosis means you are able to tap into the body’s fat stores, metabolizing fat for immediate energy and producing ketones for fuel. Furthermore, the ketogenic diet has been shown to reduce circulating insulin levels, which may lead to less storage of fat by the hormone insulin. While both “low-carbohydrate” and ketogenic diets are effective for weight loss, studies have demonstrated that the ketogenic diet is superior.
Other key points include:
Endurance Performance: Traditionally, endurance athletes tend to consume a high amount of carbohydrates in order to “fill up” their fuel stores (i.e. glycogen) for competitions. Thus, a diet where carbohydrates are restricted seems counter-intuitive for these individuals. However, Dr. Jeff Volek’s research showed that once an individual is keto-adapted, not only is their performance the same or better than those consuming high levels of carbohydrates, but their glycogen “fuel stores” are the same as well. Despite consuming a diet lower in carbohydrates, these athletes are able to adapt and utilize a nearly limitless supply of fat as their primary fuel source.
Therapeutics: The ketogenic diet was originally developed in the 1920s as an alternative therapeutic option to treat children suffering from drug-resistant epilepsy. Since its inception, the utilization of the ketogenic diet has expanded as a therapeutic treatment for many other conditions such as Alzheimer’s disease, Parkinson’s disease, GLUT-1 deficiency syndrome, Bipolar disorders and even cancer.
Quite simply, for the majority of people, the answer to whether the keto diet is safe is a resounding “yes!” Due to its high-fat nature, it is often perceived as a health risk, which often deters individuals from trying it. Despite this misconception, research has demonstrated that the ketogenic diet is safe for most people, providing you don’t have one of the following conditions (even if you have any of these conditions, the ketogenic diet may still be safe, but you would need to work very closely with your doctor):
Isn’t Fat Bad? Unfortunately, it has been ingrained into society that consuming dietary fat is detrimental to our health. Due to early “research” by individuals such as Ancel Keys, these concepts have plagued our perceptions of dietary fat for several decades. Dietary fat, when consumed alone, isn’t the culprit for bad health, but rather it is the pairing of high amounts of fat and high amounts of carbohydrates in meals (i.e., fast food) driving the issues. This high fat and carb combination has led to the many serious health problems we face today, giving rise to the quote, “Don’t blame the butter for what the bread did.”
For more information on Ancel Keys, check out the book The Big Fat Surprise by Nina Teicholz.
Supplemental, or exogenous ketones, are gaining momentum in the ketogenic community. As such, it has piqued the interest of those curious about the ketogenic lifestyle. Exogenous ketones are synthetic ketones that, upon ingestion, can increase blood ketone levels. Exogenous ketones come in both powder and liquid form:
It is important to note that consuming these supplements does not mean that an individual is “keto-adapted.” While these products can acutely put one’s body into a state of ketosis, which may alleviate “keto-flu” symptoms for some, most individuals use ketone supplements in conjunction with a ketogenic or low-carbohydrate diet.
Tip: Consuming a moderate dose of exogenous ketones during the initial “keto-adaptation” period could potentially accelerate the “adaptation,” while at a minimum increasing energy production. Once one is adapted, these products are excellent for achieving higher blood-ketone levels, which, in turn, can be beneficial for athletic and cognitive performance, energy production, and perhaps more effective therapeutic treatment.
The answer to this question of how long it takes to get into ketosis is often individualized and will depend on the metabolic state of each individual. One can enter a state of ketosis after an overnight fast. However, this slight elevation may not be high enough to allow for your body to efficiently utilize these ketones as a primary fuel source. Over time, as you become more adapted, your body will consistently be producing AND utilizing ketones. For some, this could take as little as one week, however, for others, it could take several weeks to accomplish. The length of time it takes to become keto-adapted also greatly depends on the composition of the ketogenic diet utilized (i.e., 20 grams versus 50 grams of carbohydrates per day) as well as personal activity level.
Despite the benefits of a keto diet for beginners, some individuals may experience side effects during the initial “keto-adaptation” process. Again, this will vary depending on the individual. The set of common side effects associated with keto-adaptation have been collectively coined the “keto-flu.”
The “keto-flu” is a term used to define the period of discomfort that accompanies the biological changes that occur when switching the body’s primary fuel source from carbohydrates to fats. With symptoms that often feel like an illness, the “keto-flu” may be characterized by the symptoms depicted above. Again, if one’s ketogenic diet has been well formulated, many of these symptoms may not occur or can be alleviated through proper electrolyte supplementation. Symptoms include:
Cravings: As one begins to eliminate carbohydrates from the diet, it is common to experience carbohydrate cravings. Several suggestions for conquering these cravings are outlined below. However, it should be noted that as the body keto-adapts, hunger and appetite should become suppressed. One interesting study found that when you increase the occupied volume inside of the stomachs of subjects, this led to feelings of perceived fullness. This means by doing things like drinking more water and eating more high-volume foods we can improve our feeling of fullness.
Headaches: Headaches can be a common symptom of the “keto-flu.” Outlined below are several options to help alleviate the symptoms:
Cramps: Due to the initial release of water when starting a keto diet for beginners, people often forget to replenish and hydrate. Due to this, some may experience “dry mouth.” An effective remedy is to ensure that there is sufficient consumption of water coupled with electrolyte balance. If dehydration persists, an increase in electrolytes may be needed (especially magnesium).
Decreased Energy: In order to cope with this symptom, several options below may be consumed during this “adaptation” phase:
Constipation: As mentioned above, the elimination of carbohydrates coupled with the increased release of water may lead to constipation. If this occurs, simply increasing water consumption as well as incorporating more fiber into the diet can alleviate these symptoms. Additionally, some electrolytes like magnesium can also assist with this in higher amounts.
Understanding which foods to eat may seem like the most difficult and time-consuming task for most individuals adopting a keto diet for beginners. However, you will soon realize that many of your favorite foods can still be enjoyed without the carbohydrate load. To start, it should be noted that it is critical to eliminate sugar or any fast-digesting carbohydrates. These include, but are not limited to: cookies, chocolate, cakes, crackers, ice cream, cereal, pretzels, pastries, baked goods, fruit juice, soft drinks, honey, candy, chips, bread, and white potatoes. However, there are ways to still enjoy some of these foods as long as they are prepared differently by using ketogenic-friendly ingredients. Check here for more recipes and try these tips:
Tip: When shopping, become accustomed to reading nutrition labels, paying careful attention to “sneaky carbohydrates” that may be included in dressings, sauces, and dips, which can add up quickly and knock individuals out of ketosis.
When adopting a keto diet for beginners, ensuring that it has been “well-formulated” is indispensable. Unfortunately, this critical factor is often overlooked and makes adherence to this diet very difficult. In addition, taking into consideration food quality and micronutrients are also just as critical. A well-formulated ketogenic diet will also aid in the prevention or alleviation of the side effects/”keto-flu” that are often experienced with the keto-adaptation process. To help create a well-formulated ketogenic diet, some points of consideration are outlined below:
Fiber: Adequate fiber ensures that you have proper digestive function and may aid in the prevention of constipation.
Water: As mentioned above, you can rapidly excrete out water on a keto diet for beginners. To prevent dehydration, consumption of more water than one is typically accustomed to will be necessary. If an individual experiences lightheadedness, brain fog, constipation, or headaches, dehydration may be the culprit.
Electrolytes: Due to the increased water expulsion by the kidneys, many electrolytes are simultaneously lost. Electrolyte imbalances are heavily responsible for feeling the “keto-flu.” Important electrolytes one must consider replacing: sodium, potassium, and magnesium. These electrolytes can be replenished by increasing your intake of certain foods and/or supplementation.
Here is our user-friendly, step-by-step guide to creating a ketogenic meal:
Choose a Protein Source: Typically, it’s easier to choose a fattier protein source such as red meat, eggs, salmon, or chicken thighs. However, leaner meats will likely still work; fat will just have to be added elsewhere.
Add High-Fiber Vegetables: Selection preference is given to cruciferous, dark leafy greens. Salads following the suggested criteria for a well-formulated ketogenic diet are always an excellent option.
Top with Fat: In order to fill in the rest of our calories, you can add in fat on a ketogenic diet (i.e. butter on top of a steak). This macronutrient can be achieved through the incorporation of full-fat salad dressings, butter, or oils (e.g., coconut, olive oil), full-fat cheeses (in moderation) and lower carbohydrate nuts.
Snacking on a ketogenic diet is not a requirement but a personal choice made on a daily basis. We encourage people to snack as little as possible and most individuals feel extremely satiated on a ketogenic diet. Some easy, low-carb snacks on the go if hunger arises are:
Using the tips below, maintaining a ketogenic lifestyle while dining out can be stress-free.
As one embarks on a ketogenic lifestyle, there are major changes that need to occur—aside from the biological adaptations—in which there does exist a learning curve. Below are common mistakes that individuals can make when adopting a keto diet for beginners:
It’s time to take that next big step and start your ketogenic lifestyle today! Having a community of supporters to encourage you along the way can make the transition much easier. Become a part of our ketogenic.com community and start your keto transformation today! For even more support, check out the Ketogenic Community on Facebook
There are several strategies for transitioning into a ketogenic state. Depending on a variety of factors and lifestyle habits, some individuals choose to ease into the process by adopting a low carbohydrate diet prior to implementing a full keto diet for beginners. One place to start would be to eliminate sugary, processed foods and replace those with whole, lower-carbohydrate foods. In doing so, you will begin to understand the keto diet for beginners, and once ready, you can dive into and customize the diet. To aid in the transition of a ketogenic lifestyle, our Keto Calculator is an excellent resource!
We are excited to see that there are a growing number of physicians who are implementing the ketogenic diet as a therapeutic treatment option for patients suffering from various diseases/conditions. Due to the difficulty in locating these doctors, be sure to use our Keto Doctors tool to find a ketogenic doctor near you!
Keto-adaptation occurs as tissues maximally increase their capacity to utilize ketone bodies for fuel. As glucose metabolism slows and fatty acid breakdown ramps up, ketones are synthesized and increasingly utilized for fuel. After a few weeks or months of increasing ketone and fat utilization, the body adapts to these new fuel sources. In addition to increased fat breakdown and ketone synthesis and utilization, keto-adaptation is associated with decreased and stabilized blood glucose levels.
In order to increase uptake in your cells, your body must increase the transporters (or tunnels) that take up ketones. As you continuously build up tunnels/transporters, you will be able to take up and utilize ketones with greater efficiency.
Among the many biological modifications that must occur for sufficient ketone body utilization, the upregulation of ketone transporters must take place. Thus, research has demonstrated that chronic elevations in blood ketone levels positively increase the number of these transporters. Therefore adherence, especially during the initial stages of the keto diet for beginners, is critical.
Once “keto-adapted,” many tissues increase their capacity to utilize ketones for fuel. Some tissues even prefer to use ketones for their cellular energy needs. For instance, the heart, as well as many areas of the brain, prefers to use ketone bodies as opposed to glucose. One interesting fact is that Dr. Stephen Cunnane found that the uptake of ketone bodies in the brain is proportional to their production. Additional research has also demonstrated that as uptake of ketones increases, the uptake of glucose decreases in brain tissue. In contrast, there are certain cells that cannot use fatty acids or ketone bodies, and are considered “obligate glucose users.” Red blood cells and specific parts of the brain are obligate glucose users. Don’t stress, however, because even though you may not be consuming a lot of carbohydrates, these cells can obtain glucose through a biological process called gluconeogenesis (the production of glucose from other non-glucose materials).
In addition to the “keto-flu,” many individuals may also experience impaired physical performance as the body adapts to the shift in fuel sources; however, this is only temporary and performance should be recovered upon full adaptation. As such, decreased performance may be expressed as:
Research on the performance measures following the first six days of a keto diet for beginners have found that performance suffers. However, an additional study found that after a month of ketogenic dieting, performance did not suffer.
Therefore it may not be a great idea to start a keto diet for beginners close to a competition or performance-based event. Instead give yourself a couple of weeks to fully adapt.
Blood Lipids on a Ketogenic Diet: Lack of proper education has incorrectly held a high-fat diet responsible for an increase in blood lipids. Decades of research, combined with efforts to shift the paradigm, are now revealing that increased dietary fat consumption does not directly result in increased blood lipids. It is actually carbohydrate consumption that tends to increase total cholesterol with noticeable decreases in the HDL “good” cholesterol. Often, researchers use a “high-fat diet” interchangeably with a “Western diet;” many confuse the term “high-fat diet” in the research with a ketogenic diet. A “high-fat diet” in the research indicates a diet with both high-fats and high-carbs, which is associated with increased blood lipids, whereas a ketogenic diet is not.
For example, here are a couple studies that have looked at this directly:
For more information on LDL and the lack of association with CVD, check out this review paper.
Keto for Diabetes: The ketogenic diet can be an extremely effective therapeutic treatment for diabetes. Since type 2 diabetes is hallmarked by insulin resistance, a ketogenic diet may improve insulin-resistance, associated pathological state via the following:
Virta Health recently published a report showing patients could rapidly improve glycemic control through reductions in fasting blood glucose, HbA1c, and medication use after 10 weeks of treatment. Patients lost 7% of their body weight on average and reported less hunger. For more information, please visit our friends at Virta Health who are actively working with diabetics (https://www.virtahealth.com).
Here are a few studies that have seen improvements regarding insulin sensitivity with a ketogenic diet:
Keto for Epilepsy: The ketogenic diet originated in the 1920s as an effective treatment for children suffering from drug-resistant epilepsy. Since then, its highly successful applications have expanded to treat adult epileptic patients as well. This was an important progression in treatment because, despite the introduction of anticonvulsant drugs in the 1930s, at least one third of patients suffering from epileptic seizures are still fully resistant to anticonvulsant drug therapy. Early studies found that, when placed on a ketogenic diet, 12% of children suffering from epileptic seizures experienced full remission and 42% saw a reduction in seizures.
In pediatric patients whose seizures could not be treated with these anti-epileptic drugs, a ketogenic diet was able to reduce seizures by more than 50% in 54% of the young patients tested, with 10% of the cohort becoming seizure-free after one year on the diet. Since this study, numerous additional studies have shown this modality to be effective for children and adults with epilepsy. Results of ketogenic diet–driven studies have included 55% of patients seeing a reduction in seizures by more than 50%, and 27% of patients seeing a 90% or greater reduction in seizures with many entering into complete remission.
Keto for Cancer: Cancer is now being discussed as primarily a metabolic disease in which glucose can fuel its progression. Due to recent light shed on this subject, intensive investigations are underway and have begun to reveal that restricting carbohydrate intake can slow oncogenesis and that a full ketogenic-state may elicit even greater therapeutic benefits. Furthermore, research also suggests that fasting and the state of ketosis may increase the sensitivity of cancer cells to radiation and chemotherapy.
For example, here are a couple studies that have looked at ketogenic therapies in cancer situations:
Keto for Alzheimer’s Disease: One characteristic of Alzheimer’s disease is insulin resistance in the brain (hence why it’s now being referred to as type III diabetes), which robs this critical tissue of energy. Limiting glucose while introducing ketones may be an effective mechanism for replenishing the energy in the tissue. The higher level of ketone production accompanied with a ketogenic diet is another example as to why this diet is superior to one that simply restricts carbohydrate intake. Additionally, Alzheimer’s disease is characterized by beta-amyloid deposition, which may also be mitigated by the implementation of a ketogenic diet.
Keto for Parkinson’s Disease: Parkinson’s disease develops as a result of neuron death in the midbrain and is typically accompanied by tremors, as well as physical and cognitive impairments. Due to its neuroprotective effects, the ketogenic diet may help protect neurons, increase energy production and mitochondrial function, lower inflammation, and improve motor function—all of which play a role in Parkinson’s disease.
For example, one study with five patients diagnosed with Parkinson’s disease who adopted a ketogenic diet saw a 43.4% reduction in the Unified Parkinson Disease Rating Scale.
Keto and Traumatic Brain Injury (TBI): Research involving TBI has found that upon immediate trauma to the head, the brain takes up massive amounts of glucose. However, soon thereafter, the brain becomes resistant to taking up and utilizing glucose. This damage leads to insulin resistance and inflammation of brain tissue. The anti-oxidative and anti-inflammatory properties of ketones have been shown to not only reduce inflammation but to reduce glucose uptake in the brain as well. The ketogenic diet may also be a therapeutic treatment option for those individuals who have experienced long-term ramifications of a TBI by providing ketones as an alternative fuel source that can be readily taken up and utilized by the brain following these traumas.
Emerging Areas: In addition to the current therapeutic applications of a ketogenic diet, below are some of the emerging areas of investigation:
Though it’s possible, studies have shown that once you are adapted, you could transition to eating low carb for a few days/weeks before going back to strict keto. However, it is important to understand that this flexibility should come after you are adapted and not just in the beginning.
If you “slip up” on a ketogenic diet, it is not the end-of-the-world nor does it mean you should continue to be off the wagon. Unfortunately, having frequent “slip-ups” or “cheat days” may prevent you from becoming “keto-adapted.” However, an occasional “slip-up” for someone who is already “keto-adapted” may not be as detrimental. Get back on track and get back in your routine. Find support groups and alternative recipes to avoid these pitfalls and setbacks.
Certain alcohols, in moderation, may be well tolerated by some individuals. An example of a ketogenic-friendly red wine is Dry Farm Wines. Also, low carbohydrate beers may permit certain individuals to remain in a ketogenic state. Be sure to avoid sugary liquors and beer as well as sugar-laden mixers.
Restricting your calories may be important for some individuals depending on their goals. Additionally, it may aid in the initiation of ketosis; however, not everyone will require calorie tracking to maintain a deficit. It is not uncommon for caloric-restriction to occur inadvertently as a ketogenic diet tends to be satiating, leaving individuals satisfied with fewer calories.
A carbohydrate refeed is not necessary on a ketogenic diet, as the keto-adapted biological and metabolic changes do not require dietary carbohydrates. There are certain circumstances, however, in which an increase in small carbohydrate influx may be beneficial; however, more research is needed on this topic, specifically with respect to variations of ketogenic diet including “cyclic” and “targeted” ketogenic diets.
By definition, fasting is the absence of caloric consumption for a distinct period of time. There are several different fasting strategies: intermittent, alternate day, and even several days.
Fat-fasting is the consumption of only the macronutrient “fat” during the fasting period. An example is drinking coffee all day, with fats like heavy whipping cream, butter, or coconut oil added in. Some research has shown that since this doesn’t increase insulin, it mimics a fasting state.
Among the many benefits of being in a ketogenic state is muscle preservation. Research has demonstrated that ketones prevent muscle catabolism. Furthermore, muscle anabolism may actually occur once “keto-adapted.” For these reasons alone, the ketogenic diet still would allow you to maintain or increase muscle mass.
Exogenous ketones are molecules that, upon consumption, behave similarly to the endogenous ketones that the body produces due to carbohydrate restriction.
At first, you may experience intense hunger; however, if your diet is well formulated, hunger tends to subside once your ketones become elevated and your blood glucose stabilizes.
MCTs are fatty acids that are structurally shorter than long-chain triglycerides, which require processing from the gallbladder. As such, MCTs are rapidly digested and directly used for energy, with a lower propensity for fat storage. These fats are a staple on the ketogenic diet, in which they can be converted to ketones!
Not all fats are created equal! Omega-6 fatty acids, as well as “trans” fatty acids, should be limited or completely avoided if possible. Rather, one should focus on a diet rich in Omega-3 fatty acids, which have anti-inflammatory properties. Make sure you are limiting vegetable oils!
ketogenic.com suggests tracking total carbohydrates (fiber + non-fiber carbohydrates) in the initial stages of “keto-adaptation;” however, once adapted, one may be able to track “net” carbs (non-fiber carbohydrates – fiber).
Yes! In fact, caffeine may actually increase endogenous ketone production. However, as usual, be careful about consuming caffeine late in the afternoon, as it may affect your sleep.
Some fruits, such as berries, have a low glycemic index and are also lower in carbohydrates. If incorporating berries, try and opt for the fresh, organic, frozen berries. Don’t forget: avocados are the best fruit out there and well suited for a ketogenic diet.
As with other customized properties of the diet, the consumption of dairy is individualized. If digestive or glycemic problems develop due to the lactose and casein in dairy, then dairy may need to be avoided. If you can tolerate it, opt for lower carbohydrate dairy like cheese, heavy whipping cream, and butter, rather than higher carbohydrate products like milk.
Not necessarily. Positive results can be seen on the ketogenic diet without exercise; however, exercise will maximize the benefits of the diet. In addition, exercise may help accelerate the adaptation process and allow your body to utilize ketones better.
Tracking protein is important for anyone who has adopted a ketogenic diet. Depending on activity level and other metabolic factors, some individuals may be able to tolerate more protein. As mentioned above, at a certain level protein can be glucogenic; so tailor it to your needs. However, we would say to lean towards more, not less, especially for older individuals trying to preserve muscle mass.
Hitting a plateau on a ketogenic diet is possible regardless of one’s goal. Below are actions to consider taking to continue losing fat:
As always, check with your physician first. Despite the high-fat nature of the diet, research has shown that the ketogenic diet may actually be beneficial for improving one’s blood lipid profile.
Yes. Calories are still of importance, even on a ketogenic diet. Simply eating unlimited fat will not guarantee results.
Depending on an individual’s current metabolic state, activity levels, and goals, macronutrient profiles will vary among individuals. In general, we recommend that a beginner adopts a macronutrient ratio around 70/25/5 (fat/protein/carbohydrate) and then customize from there. For more help, check out our Keto Calculator.
One key to the longevity of a ketogenic diet is to incorporate foods that are satisfying. If individuals choose to make keto-friendly desserts, learning which sweeteners permit one to remain in a ketogenic state is essential. Ideally, we encourage natural sweeteners like Stevia, monk fruit, erythritol, and allulose in moderate amounts.
At the start of a keto diet for beginners, it is not uncommon for an individual to experience rapid weight loss. This may concern some people, but it is worth noting that not ALL weight lost is body fat. When we lower our carbohydrate intake our insulin lowers, causing us to excrete more water. Additionally, reducing carbohydrate intake causes the body to break down glycogen stores (to initially maintain blood sugar levels); glycogen is the storage form of glucose that is located in our liver and skeletal muscle. The loss of both water and glycogen accounts for most of the weight loss in the first few days. Don’t be discouraged! Soon after, total body water and glycogen levels will balance out.
I am looking for a keto Dr in the Seattle area. I have diabetes and I need monitoring my insulin. Thank you
Thanks for trying to stick to the evidence! So often these “newer” diets and therapies are not fully researched and are of peoples opinions. As a physical therapist I try to keep up on what will help my patients. This article and website will be added to my resource list. It’s not possible to be the expert on everything, so thanks for putting out quality information.
Thanks for your comment and dedication to helping your patients in an educated way!
Refreshing, just plain refreshing. Maybe it’s because I’m a nurse anesthetist and I’m more comfortable reading research or journal articles than opinions, but this is an excellent article! It addresses all the questions ,concerns and misnomer surrounding the KD. It is well written, easy to read and gave me that additional depth of understanding that I was desiring. Thank you, thank you, thank you!
This seems like a well balanced site that has done good research into this type of diet.