Insulin In Context

Every day, I see it more and more – “insulin is evil.” For dieters’ whose goal is to lose body fat, we are told to drive down insulin and that anything that raises insulin is inherently bad. This approach follows the logic for ketogenic dieting as well.  We know that for ketones to be produced, insulin has to be lowered and studies have shown that greater levels of ketones actually translates to greater amounts of body fat lost (1). Insulin is the enemy, to be constantly warred against…except it isn’t.  Conversely, we seem to see a counter-logic position that glucagon is the hero (very much the functional opposite of insulin) in both public forums and in people who lack an understanding of hormone regulation.  In reality, insulin and glucagon are regulatory hormones that, in general, control blood sugar and regulate anabolism/catabolism. This is a poorly understood concept in nutrition and biochemistry by those outside of academia. Some of that lack of knowledge or misinformation is complicating the issue. To best combat this, we are going to tackle three topics:

  • What is Insulin?
  • 2. What Does Insulin Do?
  • 3. Why is Insulin Important?

This is as distilled-down an approach that we can take. I don’t want to leave you with an unscientific understanding, so we will discuss some complex terms in as simple a fashion as possible so that by the end you will hopefully understand that insulin is not the enemy, chronic hyperinsulinemia is a problem, and there’s something we can do about it!

What is Insulin?

Insulin, by definition, is “a peptide hormone produced by the beta cells of the pancreatic islets.”  If you haven’t taken anatomy & physiology, or a course in cell biology, this probably means nothing to you. Most of us think of insulin as one of two things:

The anabolic hormone (those with a sports sciences or sports background)

The reason I’m fat (those with a history of metabolic syndrome / obesity and who have read publications espousing that theory)

The truth is that insulin is absolutely both – given the right conditions. But let’s stick to the proper definition, and ask, what is insulin?

Insulin is a peptide hormone. When you see the term “peptide” it simply means that it is made of protein. This means that the hormone is manufactured from the products of the meat (or plant-based protein) that you consume in your diet. Insulin is manufactured by the pancreas. The pancreas is a relatively small organ in the body which has both exocrine function (i.e. creates hormones and enzymes that are secreted into a duct that does not enter the common blood stream) and endocrine function (i.e. creates hormones and enzymes that are directly secreted into the common bloodstream). The pancreas has several functions. Four important functions are:

  • 1. It secretes digestive enzymes (about 90% of the pancreas is responsible for this).
  • 2. It secretes insulin (via the beta cells).
  • 3. It secretes glucagon (via the alpha cells).
  • 4. It secretes somatostatins.


Now, what are alpha cells, and what are beta cells? Functionally, beta cells are cells that store and release insulin due to the presence of elevated levels of glucose in the blood. Alpha cells perform a similar function for glucagon. They are located in the same organ, perform counter-functions, and are triggered by the relative presence or absence of glucose in the blood. Both are absolutely required for human survival!

What Does Insulin Do?


When blood glucose is well-regulated and at baseline or reasonably low levels, the secretion of insulin is slowed or stopped. When glucose is increased (due to consumption of carbohydrates, for example) insulin secretion springs into action. Why is this important?  Most fail to understand how little glucose is in the blood supply at any given time when they are “walking around.” I use that term to imply that they haven’t recently awakened nor recently fed.  The answer to how much is about 5 grams, or roughly a teaspoon of glucose. There is a direct correlation between the relative amount of sugar in a substance and its thickness. Consider pancake syrup and how the sap is runny, whereas the finished syrup is thick; water that has been removed increases its concentration. Likewise, if glucose cannot be cleared from blood, your blood thickens, which not only creates damage in terms of potential hypoxia but also makes the system work harder and can cause blood vessel damage.

Insulin is the primary mechanism by which cells are made to take glucose in for storage. We need insulin because cells of the human body are surrounded by a semi-permeable outer layer (only some things can get in without help). To help explain this better, let me use an example of a recent experience I had at a concert:

  • Insulin is a cute girl.
  • Glucose is a goofy fan who wants to get into the show.
  • The cell membrane is the bouncer.

Glucose would like to get into the show, but the bouncer says no. Insulin takes pity, tells the bouncer, “He’s with me,” so that goofy glucose gets into the show, and then the cute girl walks away, having done her good deed for the day.



Now that we have a vision in mind, let’s talk about it in a more scientific manner. When the relative level of glucose in the blood is too high, insulin is secreted. Insulin traverses through the body and arrives at the surface of the cell membrane, and a complex process occurs where the Glucose Transporter Type 4 (GLUT4)  signaling pathway is activated, which causes a GLUT4 to migrate to the surface. There, they begin to actively transport glucose from the blood supply into the cells where it can be:

  • 1. Used for Fuel
  • 2. Stored for Future Fuel (converted to glycogen)

Why is Insulin Important?

The net effect of insulin secretion is to drive glucose into the cells and out of the circulating blood. Without insulin’s ability to regulate glucose, life could not be sustained. If we need evidence of this, consider the fate of type I diabetes without supplemental insulin. It becomes a wasting disorder meaning the person functionally starves to death on a cellular level.

When we speak of insulin as being anabolic (as many bodybuilders and powerlifters often do), we understand from looking at glucose that insulin can be viewed as the master hormone that drives glucose into cells…but it also has an effect on fat and protein.


Insulin Summary

  • The presence of insulin in reasonably high amounts seems to override any physiologically possible level of glucagon and retains stored body fat within the adipocytes as well as driving dietary fat into storage.
  • The presence of insulin aids in transferring 1.) amino acids from the blood and 2.) creatine into the muscle cells. This aids not only in recovery but also in the reduction of catabolizing muscle tissue in the absence of sufficient caloric intake.
  • For the purpose of full disclosure, know that there are GLUT4 receptors in human muscle cells that respond to resistance training but not to insulin, and so any thought that insulin is required for muscle synthesis or recovery is likely inaccurate. However, the possibility that insulin is potentially advantageous is still up for debate and an active area of ketogenic diet and performance science research.

In this frame of reference, you begin to recognize how insulin and glucagon are both required, useful, and more in-depth than what I have presented here. As a last analogy to serve this article let me borrow an analogy that I used to teach a high school class on how to think of insulin and glucagon.


When we take a drink and set the glass down, we are executing what is functionally a biceps curl. Speaking very generally, we have a primary or agonist muscle (the biceps) and an antagonist muscle (the triceps). Regulatory hormones and enzymes are often the same way. There is a switch or a cascade of switches that can turn their function on or off, but they function in both directions. Just as bringing the glass to your mouth, your biceps is performing a concentric movement. The triceps keeps tension against the joints for stability and control, and, upon returning the glass to its original position, the triceps shortens while the biceps lengthens. Insulin and glucagon can be viewed in the same fashion. They keep constant tension upon the regulation of a number of functions within the body, not the least of which are:

  • 1. Fat Mobilization
  • 2. Protein Synthesis and Anabolism in General
  • 3. Blood Glucose Regulation


Insulin is not “bad” in the short term.  It is the chronic elevation of insulin levels, as seen commonly in our society today, which are indicative of poor health, coupled with the evidence that glucose levels in the blood can remain high because the cells are not responding to the signal of insulin as they should (i.e. insulin resistance). Insulin is not to be feared, but rather, it is simply to be understood.

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