Well, here we are. The Game Changers documentary has gone live and the world is in shambles. The producers and director(s) did a fine job showing their side of the story, but the problem is that documentaries are typically designed to do just that: share one side of the story.
Since the documentary was mostly centered around athletic performance and building muscle, here’s a rebuttal from the other side of the matter that, frankly, isn’t nearly as biased about plant protein vs animal protein. You see, while this article is being presented on ketogenic.com, I am an outside contributor with no association with the ketogenic diet. I have no problem with the ketogenic diet, I just simply like doughnuts and pancakes too much to go keto.
With this in mind, let’s have an objective discussion on the scientific findings of the difference between plant and animal proteins and how they affect muscle growth and performance. Not potential health markers, not spirituality, and not climate change… just muscle and performance. All other factors are for arguments far outside the scope of this article.
Hopefully this preemptive statement does the trick in preventing tempers from flaring and accusations from flying, but it is 2019, so I’m sure someone will find a way around it. We can’t worry about that forever, though, so let’s get started.
Plant Protein vs Animal Protein: Why Compare?
It’s worth taking the time to compare protein sources because:
2) Health, longevity, and quality of life are all greatly correlated with lean muscle and strength. 
3) Lean muscle mass is greatly predicated on the balance between muscle protein synthesis and protein breakdown. 
4) Different sources of protein can induce different effects on the rate of muscle protein synthesis. 
Therefore, comparing animal protein sources with plant protein sources makes perfect sense. Plant and animal proteins can induce different rates of muscle protein synthesis which can affect muscle growth, strength, performance, and even longevity. Therefore, it’s certainly worth looking into what the exact differences between these protein sources are.
What Drives Muscle Protein Synthesis?
As mentioned above, lean muscle mass is either increased, maintained, or decreased depending on the balance between protein synthesis and protein breakdown. Positive protein balance elicits increases in muscle size and is driven by an increase in protein synthesis [32, 34]. Negative protein balance can occur from a lack of food (or energy in general) and can ultimately cause a decrease in muscle size due to protein breakdown occurring at a faster rate than protein synthesis.
The two main precursors to protein synthesis are exercise and food intake – primarily protein [13,18,21]. Most forms of exercise will cause an increase in muscle protein synthesis with resistance training leading the pack . However, damaging exercise (like heavy training) can also increase protein breakdown which necessitates protein intake to drive protein synthesis higher than breakdown and create an overall positive protein balance.
Protein synthesis, by way of food, is mostly driven by essential amino acids (EAAs). EAAs, and especially BCAAs, act as signaling molecules that can help kick start the protein synthesis process .
Leucine appears to be the most important EAA for stimulating muscle protein synthesis [11,21,28,29], so the majority of the comparisons between protein sources focuses on leucine content. Leucine and EAA content certainly play a role in how well a protein source can stimulate protein synthesis, but some other factors are involved as well, so which is better: plant protein vs animal protein? Let’s get into that next.
Protein Quality, Kinetics, and Anabolic Potential
What about the overall quality of plant protein vs animal protein? Protein quality is highly related to EAA and leucine content and, up until recently, was measured by the PDCAAS scale, which stands for Protein Digestibility Corrected Amino Acid Score. However, this rating system has started to phase out and is being replaced by the DIAAS, which stands for the Dietary Indispensable Amino Acid Score .
Both systems are used to measure how much of a certain protein source would be needed to avoid protein deficiency . Avoiding deficiency certainly isn’t the same thing as optimizing lean mass gains, so these scores aren’t the most applicable right off the bat.
Both systems are great for assessing protein quality and bioavailability, but that doesn’t necessarily correlate with the anabolic potential of a protein source . For example, soy and beef protein have similar PDCAAS scores, but beef has been shown to be more effective than soy protein at increasing protein synthesis levels [20,29].
The anabolic potential of a protein source is dependent on several factors, including digestibility, amino acid absorption kinetics [12,19], and EAA composition [26,32] with leucine being the most important [28,29]. Therefore, the overall potential of a protein source to encourage muscle growth is dependent on its quality and overall anabolic potential. So how do protein sources compare?
Plant Protein vs Animal Protein: EAAs, Protein Kinetics, Digestibility, and Quality
From the charts in this section, it’s easy to see that animal-based proteins consistently have higher EAA contents and higher leucine contents. 
When protein kinetics are considered, research shows that plant proteins actually exhibit lower levels of digestibility when compared to animal proteins.  This is typically measured by the proportion of amino acids that are digested and absorbed and thus available in a form that can contribute to protein synthesis.
Animal proteins typically present with rates over 90% while plant proteins usually range between 45-80%.  However, isolated forms of plant protein, such as soy isolate or wheat gluten, often score above 90% as they are devoid of things like fiber or phytic acid which may affect digestibility. [7,29]
In addition, amino acids from plant proteins are more likely to be converted to urea than animal proteins. [4,5,8,9] This lowers the potential of plant-based proteins to increase protein synthesis as fewer amino acids will be available to promote and contribute to protein synthesis. This is more than likely due to the lack of specific EAAs in many plant proteins.
This can lead to an unfavorable amino acid mixture in the gut which increases the amount of amino acids that get shuttled to the liver, ultimately stimulating ureagenesis, or, the production of urea.  This theory has been somewhat confirmed in studies showing that soy protein causes a much greater increase in amino acid oxidation compared to milk protein when both are consumed in the same amount. 
Overall, fewer amino acids from plant proteins are used for muscle protein synthesis. 
All of the above can be summarized in the DIAAS comparison between various plant and animal protein sources, shown in the chart in the previous section. Animal proteins consistently score higher than plant proteins. [15,22]
Applicable Comparisons in Plant Protein vs Animal Protein
So, we now have all of the background science and theories behind how animal and plant proteins might differ, let’s see how this plays out in the real world. In acute ingestion, soy protein does not increase protein synthesis to the same degree as whey protein , skim milk , or beef. 
Other forms of plant-based proteins don’t have nearly as much literature on their effects on protein synthesis as they’re not as readily available or common as soy.  Therefore any claims about the gains-effectiveness of a plant-based protein other than soy should be met with appropriate skepticism.
This acute increase in muscle protein synthesis has also been shown to affect gains in the long term. Milk proteins have been shown to be more effective for lean mass gains compared to soy proteins when both are taken in the same amount and same time frame. [10,31]
In addition, fish eating a plant protein diet compared to a normal fish chow diet actually experienced decreases in muscle fiber size . However, studies do show that plant protein can be beneficial for growth, there’s just one caveat: you have to eat more!
Studies that provided higher amounts of both milk and plant proteins to subjects after a workout saw similar gains in lean mass over the long term between protein sources [6,11]. The reason for this is that both studies used at least 30g of plant-based protein. Since a higher amount of plant protein was used, the necessary leucine threshold of 2-3g was met [17,26].
If you reference the above chart concerning leucine content and protein sources, it’s easy to see that plants and whey protein could deliver similar amounts of leucine, you just have to take in more plant protein. Since the upper limit of the leucine threshold exists somewhere between 3-4g , taking in higher amounts of both will probably lead to similar increases in protein synthesis. Whey will provide leucine beyond the threshold which probably offers no additional benefits, while soy will be right in the wheelhouse of the threshold.
Plant Protein vs Animal Protein: Conclusions
So really the takeaway here is this: animal proteins are more effective for promoting protein synthesis than plant proteins. But! All you have to do to even the playing field is eat greater amounts of plant protein.
The above leucine threshold seems necessary for driving muscle protein synthesis, so all one has to do is find the right amount of their desired protein source that lands them in the sweet spot of the leucine threshold. If this step isn’t taken, it’s very easy to under-consume protein during a plant-based diet which can reduce overall lean mass, strength, and quality of life .
If one does wish to subscribe to a plant-based diet while attempting to maximize muscle growth, creatine and beta-alanine supplementation should be considered as dietary provisions of both will be much lower [22,30]. In addition, vegan/vegetarian diets and the protein sources within their confines contain much higher amounts of antioxidants . While antioxidants can improve endurance exercise performance, they can actually impair muscle growth .
Quite frankly, a plant-based diet is not optimal for muscle growth. Anyone trying to claim the opposite has some serious soul searching to do. But that doesn’t mean muscle growth is impossible! Take the information cited in this piece and use it to your advantage if you want to design a plant-based diet primed for muscle growth. Plan on eating at least 30g of plant protein at each meal to maximize muscle protein synthesis and try to avoid antioxidants around your workouts as much as possible. Taking digestive enzymes can also help improve the protein kinetics and digestibility of plant proteins .
Again, ethics and morality are far from the contents of this article. If you choose to lead a plant-based lifestyle, I completely respect that. That’s your choice and everyone else’s diet is their choice. However, it’s important to understand the objective and non-biased science behind plant-based diets and muscle growth. Growth can absolutely be achieved on a plant-based diet, however, specific steps must be taken to maximize growth – just like consuming a diet with both animal and plant sources. Optimizing your diet, no matter your primary food source, is a major component of making gains.
If you’re interested in a more in-depth discussion, check out the extensive review by van Vliet, Burd, and van Loon (2015) here. This review was of major assistance while drafting this article so credit is certainly due.
Note: One source in this piece was determined to potentially have a conflict of interest and/or bias . However, this source is only used to support a single claim that aligns well with other claims throughout the article.
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Charlie Ottinger is the Content Manager for The Muscle PhD and Generation Iron Plus. Charlie is currently working on his PhD in Human Performance and has a Master’s degree in Kinesiology and a Bachelor’s degree in Exercise Science. Before joining the research side of the field, Charlie was a strength and conditioning coach in both the collegiate and private sector. Charlie’s specialties include strength training for muscle growth and performance as well as nutrition strategies to optimize strength training adaptations and body composition.