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Is the Keto Diet the Key to Longevity?

  Published on January 13th, 2022
  Reading time: 3 minutes
  Last modified July 9th, 2023
Sign to longevity

Is the secret to living longer sitting right in front of you on your dinner plate? It’s no surprise that what we put in our bodies greatly determines how we’ll fare in the department of aging. Now, actual research is pointing to the keto diet as a means for longevity and improved cognition. Let’s explore the popular diet and the studies which exhibit increased longevity as a result of the ketogenic nutrition plan.

How Keto Works

High-fat keto diet

The keto diet employs the use of fat for fuel instead of carbohydrates. When (roughly) 75 percent of calories come from fat, the body enters the metabolic state of ketosis, turning the body into a fat-burning machine. What might this have to do with longevity?

Blue Zones are specific areas of the world where people live the longest—they are located in Okinawa, Japan; Sardinia, Italy; Nicoya, Costa Rica; Ikaria, Greece; and Loma Linda, California. 

One characteristic all these areas of longevity have in common is calorie restriction (CR). CR delays age-related diseases and increases longevity across numerous animal studies. [1] Coincidentally, CR provokes a change from carbohydrate to fat metabolism. Low-carbohydrate diets such as keto also cause a swing in the direction of fatty acid oxidation, and away from carbohydrates. The keto diet (which is also low-carb) has been demonstrated to foster an anti-inflammatory metabolic state, and to boost quantities of ketone bodies in mice, mimicking significant traits of CR. [2]

Mice Studies Show Increased Lifespan and Memory

The mice studies were conducted using two different groups—one group was fed a ketogenic diet with 70 to 90 percent of their calories coming from fat. The control group’s diet had a much larger proportion of carbohydrates, and only 13 to 17 percent of daily calories coming from fat.

When compared to the high-carbohydrate group, the mice following the high-fat ketogenic protocol had decreased midlife mortality rates and increased life spans, along with improved cognitive function. In addition, motor function, muscle mass, and skeletal muscle were preserved in aged ketogenic mice. [3]

Implications for Humans

While these studies were conducted in animal trials, the results are promising so it is hopeful that the same conclusions may be reproduced in humans. Since the fat-burning state of ketosis resembles the mechanisms of calorie restriction, greater longevity in humans who follow the keto diet may be experienced—like the populations of the Blue Zones that have less caloric intake.

Counting calories and macros

In addition, to calorie restriction, another characteristic of the Blue Zone diet is limited sugar. Sugar has been proven, time and again, to cater to blood-sugar related diseases, cancer, inflammation, and heart disease. The ketogenic diet’s extremely low-sugar protocol is another consideration to be taken seriously with regard to living longer, and healthier.

Are You Looking to Boost Your Longevity with Keto?

Ketogevity is an interactive tool that helps determine your strengths, weaknesses, and biological age to provide you with a personalized plan to improve your health and longevity. Check it out now to get started on your path to wellness!

Aimee Aristotelous, author of The 30-Day Keto Plan, Almost Keto, Super Simple Keto, The Whole Food Pregnancy Plan, and The Doctors Weight Loss Diet is a certified nutritionist, specializing in ketogenic and gluten-free nutrition. Her expertise has been featured in Health, People, HuffPost, Parade, Yahoo!, INSIDER, Motherly, Consumer Health Digest, Simply Gluten-Free, Well + Good, and the National Celiac Association. Aimee resides in Fort Lauderdale, Florida, with her husband and son, and enjoys cooking, working out, wine tasting, and traveling.



Speakman JR, Mitchell SE. Caloric restriction. Mol Aspects Med. 2011 Jun;32(3):159-221. doi: 10.1016/j.mam.2011.07.001. Epub 2011 Aug 10. PMID: 21840335.


Meidenbauer JJ, Ta N, Seyfried TN. Influence of a ketogenic diet, fish-oil, and calorie restriction on plasma metabolites and lipids in C57BL/6J mice. Nutr Metab (Lond). 2014 May 22;11:23. doi: 10.1186/1743-7075-11-23. PMID: 24910707; PMCID: PMC4047269.


Roberts, M. N., Wallace, M. A., Tomilov, A. A., Zhou, Z., Marcotte, G. R., Tran, D., Perez, G., Gutierrez-Casado, E., Koike, S., Knotts, T. A., Imai, D. M., Griffey, S. M., Kim, K., Hagopian, K., McMackin, M. Z., Haj, F. G., Baar, K., Cortopassi, G. A., Ramsey, J. J., & Lopez-Dominguez, J. A. (2017). A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell metabolism, 26(3), 539–546.e5. https://doi.org/10.1016/j.cmet.2017.08.005

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